Research: Lagos psychiatric hospital partners U.S. Centre on clozapine therapy      

Research: Lagos psychiatric hospital partners U.S. Centre on clozapine therapy      

By Lilian U. Okoro, Lagos.


The Federal Neuro-Psychiatric Hospital, Yaba, Lagos, has partnered with the University of Maryland Psychiatric Research Centre (MPRC) in the U.S., to conduct research on the safety of “clozapine” therapy among black people.


The Medical Director of the hospital, Dr Olugbenga Owoeye, made this known at a news conference organised by the hospital on “Clozapine Safety Study Among Black People” on Thursday in Lagos.


Owoeye said one of the disease conditions treated in the hospital was a major debilitating mental health condition called “schizophrenia” (a mental health disorder).


He noted that the schizophrenic condition was one of some certain mental health conditions resistant to conventional medications.


Owoeye also said that no matter what the doctor would do, the patient with the condition would not just improve.


According to him, there is a new medication developed to treat those mental health conditions that are not responding to conventional/normal medications.


Owoeye said that the newly developed medication, known as “clozapine therapy”, also had its side effects.


He said that “clozapine is an anti-psychotic medication used for treatment of resistant schizophrenia.


“It is also used to help reduce the risk of suicidal behaviour in people with schizophrenia or similar disorders.


“The major side effect of clozapine is that it reduces the level of white cell count of the blood, specifically the neutrophils count.


“If the white blood cell reduces, the clozapine treatment has to be suspended, until the cell increases to a certain level.


“But black people generally have low white blood cell count, compared to their black American counterparts. This is due to the genetic makeup of the black people.


“But what this research has brought out is that black people, despite their low white blood cell count, can benefit from the clozapine treatment,” Owoeye said.


Dr Richard Adebayo, Team Lead, Clozapine Study, Federal Neuro-Psychiatric Hospital Yaba, identified cost and availability of the clozapine therapy as barriers to its accessibility and acceptance in Nigeria.


Adebayo, also a consultant psychiatrist, said that the research had benefited a lot of patients, staff and the hospital, as a whole.


He said that many patients were treated for six months with the expensive medication, offered free of charge.


According to him, the Federal Government has subsidised the medication, including some other psychiatric treatments.


“This study is an added advantage to the hospital. It has brought in high-level technical equipment to the hospital.


“An equipment used for measuring the blood level that cost over N6,000,000 is secured in the course of the study. And since then, the equipment has become an asset of the hospital,” he said.


Also speaking, Dr Deanna Kelly, Acting Director, Maryland Psychiatric Research Centre (MPRC), called for continuous support and collaboration of the hospital in developing modifiable psychiatric medications.


Kelly said that the hospital was the first in the West African sub-region to engage in such kind of research.


She pledged the commitment of MPRC to partnering with the hospital in providing new developments that would enhance mental health service delivery in Africa.

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